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Article

Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis

9 Dec 2020

Abstract excerpt

Functional contributions of individual cellular components of the bone-marrow microenvironment to myelofibrosis (MF) in patients with myeloproliferative neoplasms (MPNs) are incompletely understood. We aimed to generate a comprehensive map of the stroma in MPNs/MFs on a single-cell level in murine models and patient samples. Our analysis revealed two distinct mesenchymal stromal cell (MSC) subsets as pro-fibrotic...

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PMID: 33301706
DOI: 10.1016/j.stem.2020.11.004

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