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Neutrophil-Derived S100A8/A9 Drives Inflammation that Promotes <i>Dnmt3a</i> -Mutant Hematopoiesis

2026-06-27

Abstract excerpt

Clonal hematopoiesis (CH) is an age-associated condiion defined by over-representation of hematopoietic stem cells (HSCs) and their progeny carrying somatic mutations or variants that confer a selective advantage. CH is associated with increased risk of hematologic malignancies (1), cardiovascular disease and inflammatory bone loss (2, 3). Chronic inflammation is increasingly recognized as a central mediator of CH...

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Literature Corpus work: 44d13a8a-eafc-53d6-ae7d-8dd05822173e
DOI: 10.64898/2026.06.26.734778

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