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Myelodysplasia is in the niche: novel concepts and emerging therapies

14 Nov 2014

Abstract excerpt

Myelodysplastic syndromes (MDSs) represent clonal disorders mainly of the elderly that are characterized by ineffective hematopoiesis and an increased risk of transformation into acute myeloid leukemia. The pathogenesis of MDS is thought to evolve from accumulation and selection of specific genetic or epigenetic events. Emerging evidence indicates that MDS is not solely a hematopoietic disease but rather affects...

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PMID: 25394715
DOI: 10.1038/leu.2014.325

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