Article
The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype.
Blood - 22 Dec 2016
Basiorka Ashley A, McGraw Kathy L, Eksioglu Erika A, Chen Xianghong, Johnson Joseph, Zhang Ling, Zhang Qing, Irvine Brittany A, Cluzeau Thomas, Sallman David A, Padron Eric, Komrokji Rami, Sokol Lubomir, Coll Rebecca C, Robertson Avril A B, Cooper Matthew A, Cleveland John L, O'Neill Luke A, Wei Sheng, List Alan F
Abstract excerpt
Despite genetic heterogeneity, myelodysplastic syndromes (MDSs) share features of cytological dysplasia and ineffective hematopoiesis. We report that a hallmark of MDSs is activation of the NLRP3 inflammasome, which drives clonal expansion and pyroptotic cell death. Independent of genotype, MDS hematopoietic stem and progenitor cells (HSPCs) overexpress inflammasome proteins and manifest activated NLRP3 complexes...
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