Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inflammatory Signatures in MDS: The Missing Link Between Genetics, Microenvironment, and Therapy.

Cells - 23 Jun 2026

Bottaro Adele, Nasso Maria Elisa, Mirabile Giuseppe, Fazio Manlio, Allegra Alessandro

Abstract excerpt

Myelodysplastic syndromes are clonal hematopoietic neoplasms in which ineffective hematopoiesis arises within the context of chronic inflammation and immune dysregulation. Growing evidence indicates that aging-associated inflammaging and inflammation-driven remodeling of the bone marrow microenvironment are not secondary phenomena, but active forces that shape clonal selection, lineage commitment, and disease...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular Microenvironment
Share to TP53 gene
Share to Inflammation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Myelodysplastic Syndromes

Source

Open in PubMed Open full text

Identifiers

PMID: 42439614
DOI: 10.3390/cells15131137
PMCID: PMC13360231

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inflammatory Signatures in MDS: The Missing Link Between Genetics, Microenvironment, and Therapy.PMID 42439614Read ↗

Inflammatory Signatures in MDS: The Missing Link Between Genetics, Microenvironment and TherapySemantic proximity Read ↗

Inflammation in myelodysplastic syndrome pathogenesis.Semantic proximity Read ↗

Immune Dysregulation and Recurring Mutations in Myelodysplastic Syndromes Pathogenesis.Semantic proximity Read ↗

Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDSSemantic proximity Read ↗

Inflammatory Mesenchymal Stromal Cells and IFN-responsive T cells are key mediators of human bone marrow niche remodeling in CHIP and MDSSemantic proximity Read ↗

The genetic and molecular pathogenesis of myelodysplastic syndromes.Semantic proximity Read ↗

Identification of novel myelodysplastic syndromes prognostic subgroups by integration of inflammation, cell-type composition, and immune signatures in the bone marrowSemantic proximity Read ↗

Chronic myelomonocytic leukemia: molecular pathogenesis and therapeutic innovationsSemantic proximity Read ↗

Epidemiology and Pathogenesis of Myelodysplastic Syndrome.Semantic proximity Read ↗

Identification of novel myelodysplastic syndromes prognostic subgroups by integration of inflammation, cell-type composition, and immune signatures in the bone marrow.Semantic proximity Read ↗

Clonal hematopoiesis and inflammation: A review of mechanisms and clinical implications.Semantic proximity Read ↗

SOHO State of the Art Update and Next Questions: Biology and Treatment of Myelodysplastic Syndromes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.