Article

TLR7 ligation augments haematopoiesis in Rps14 (uS11) deficiency via paradoxical suppression of inflammatory signalling and enhanced differentiation

2020-07-06

Abstract excerpt

Myelodysplastic syndrome (MDS) is a haematological malignancy characterised by blood cytopenias and predisposition to acute myeloid leukaemia (AML). Therapies for MDS are lacking, particularly those that impact the early stages of disease. We developed a model of MDS using zebrafish using knockout of Rps14, the primary mediator of the anaemia associated with del (5q) MDS. These mutant animals display dose- and age...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1310ffa8-abbe-5548-99c9-58e655b8d111
DOI: 10.1101/2020.07.06.175000

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TLR7 ligation augments haematopoiesis in Rps14 (uS11) deficiency via paradoxical suppression of inflammatory signalling and enhanced differentiationDOI 10.1101/2020.07.06.175000Read

A Zebrafish Model of 5q-Syndrome Using CRISPR/Cas9 Targeting RPS14 Reveals a p53-Independent and p53-Dependent Mechanism of Erythroid Failure.Semantic proximity Read

Preclinical Efficacy of Tasquinimod in Myelodysplastic Neoplasms: Restoring Erythropoiesis and Mitigating Bone LossSemantic proximity Read

Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) MDSSemantic proximity Read

Targeting inflammation in lower-risk MDSSemantic proximity Read

Toll-like receptor alterations in myelodysplastic syndrome.Semantic proximity Read

Splicing of erythroid transcription factor is associated with therapeutic response in myelodysplastic syndromesSemantic proximity Read

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen.Semantic proximity Read

Inhibition of NLRP1 Inflammasome Activation by Tyrosine Kinase Inhibitors Restores Erythropoiesis in Diamond-Blackfan Anemia SyndromeSemantic proximity Read

IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cellsSemantic proximity Read

New insights into 5q- syndrome as a ribosomopathySemantic proximity Read

Colony stimulating factor 1 signaling regulates myeloid fates in zebrafish via distinct action of its receptors and ligandsSemantic proximity Read

Iron Chelation Improves Ineffective Erythropoiesis and Iron Overload in Myelodysplastic Syndrome MiceSemantic proximity Read