Article

Genetic Mapping of All Human Paralog Pairs to Characterize Synthetic Lethality and Buffering

2024-07-19

Abstract excerpt

<h4>SUMMARY</h4> Paralogs are abundant in the human genome and thought to be a primary source of synthetic lethality, yet the vast paralogome remains largely uncharacterized. A digenic screen of all paralogous gene pairs in the human genome revealed that synthetic lethalities were infrequent and varied in penetrance in different tumor backgrounds. We hypothesized that the variable penetrance of synthetic lethalit...

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Literature Corpus work: 407ff58f-9371-5dea-b7d0-364db82c81f3
DOI: 10.1101/2024.07.16.603642

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