Article

Beyond synthetic lethality: charting the landscape of clinically relevant genetic interactions in cancer

2018-01-24

Abstract excerpt

The phenotypic effect of perturbing a gene’s activity depends on the activity level of other genes, reflecting the notion that phenotypes are emergent properties of a network of functionally interacting genes. In the context of cancer, contemporary investigations have primarily focused on just one type of functional genetic interaction (GI) – synthetic lethality (SL). However, there may be additional types of GIs...

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Literature Corpus work: 678700a3-78f6-563c-8764-0d640e53c5a5
DOI: 10.1101/253120

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