Article

DISC1-Dependent Antipsychotic Effects of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) Inhibitor, TC-2153, on Mice

2025-08-21

Abstract excerpt

Schizophrenia is a severe, chronic mental disorder affecting near 1% of the global population, with about 60% of patients showing resistance to currently available antipsychotic drugs (APDs). The modern dopaminergic (DA) hypothesis of schizophrenia postulates that multiple pathogenic factors contribute to hyperdopaminergia in the striatum. Therefore, effective modulation of striatal DA remains a key strategy in th...

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Literature Corpus work: 8f0563c1-496b-5107-93de-7c4938e3998b
DOI: 10.20944/preprints202508.1540.v1

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