Article
Enhanced dopamine function in DISC1-L100P mutant mice: implications for schizophrenia.
Genes, brain, and behavior - 1 Oct 2010
Lipina T V, Niwa M, Jaaro-Peled H, Fletcher P J, Seeman P, Sawa A, Roder J C
Abstract excerpt
Significant advances have been made in understanding the role of disrupted-in-schizophrenia-1 (DISC1) in the brain and accumulating findings suggest the possible implication of DISC1 in the regulation of dopamine (DA) function. A mutation in the second exon of DISC1 at L100P leads to the development of schizophrenia-related behavior in mutant mice (DISC1-L100P). We investigated here the role of DA in the...
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