Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant DISC1 affects methamphetamine-induced sensitization and conditioned place preference: a comorbidity model.

Neuropharmacology - 1 Mar 2012

Pogorelov Vladimir M, Nomura Jun, Kim Jongho, Kannan Geetha, Ayhan Yavuz, Yang Chunxia, Taniguchi Yu, Abazyan Bagrat, Valentine Heather, Krasnova Irina N, Kamiya Atsushi, Cadet Jean Lud, Wong Dean F, Pletnikov Mikhail V

Abstract excerpt

Genetic factors involved in neuroplasticity have been implicated in major psychiatric illnesses such as schizophrenia, depression, and substance abuse. Given its extended interactome, variants in the Disrupted-In-Schizophrenia-1 (DISC1) gene could contribute to drug addiction and psychiatric dise...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Conditioning, Operant
Share to Glycogen Synthase Kinase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycogen Synthase Kinase 3 beta

Share to Mental Disorders

Share to Methamphetamine

Share to Models, Animal

Share to Oncogene Protein v-akt

Share to Substance-Related Disorders

Source

Open in PubMed Open full text

Identifiers

PMID: 21315744
DOI: 10.1016/j.neuropharm.2011.02.003
PMCID: PMC3115479

Genes

DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21315744-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant DISC1 affects methamphetamine-induced sensitization and conditioned place preference: a comorbidity model.PMID 21315744Read ↗

Enhanced dopamine function in DISC1-L100P mutant mice: implications for schizophrenia.Semantic proximity Read ↗

Characterization of striatal phenotypes in heterozygous Disc1 mutant mice, a model of haploinsufficiency.Semantic proximity Read ↗

Social anhedonia as a Disrupted-in-Schizophrenia 1-dependent phenotype.Semantic proximity Read ↗

Dominant negative DISC1 mutant mice display specific social behaviour deficits and aberration in BDNF and cannabinoid receptor expression.Semantic proximity Read ↗

Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse.Semantic proximity Read ↗

Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1.Semantic proximity Read ↗

A dopamine D2 receptor-DISC1 protein complex may contribute to antipsychotic-like effects.Semantic proximity Read ↗

Effects of background mutations and single nucleotide polymorphisms (SNPs) on the Disc1 L100P behavioral phenotype associated with schizophrenia in mice.Semantic proximity Read ↗

Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans.Semantic proximity Read ↗

Disrupted‐in‐Schizophrenia‐1 (DISC1)Semantic proximity Read ↗

Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice.Semantic proximity Read ↗

DISC1-Dependent Antipsychotic Effects of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) Inhibitor, TC-2153, on MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.