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Article

The Role of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) in Cognition

1 Jan 2011

Abstract excerpt

Striatal-enriched protein tyrosine phosphatase (STEP) has recently been implicated in several neuropsychiatric disorders with significant cognitive impairments, including Alzheimer's disease, schizophrenia, and fragile X syndrome. A model has emerged by which STEP normally opposes the development of synaptic strengthening and that disruption in STEP activity leads to aberrant synaptic function. We review the...

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PMID: 21863137
DOI: 10.3389/fnana.2011.00047

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