Article
Comprehensive behavioral analysis of ENU-induced Disc1-Q31L and -L100P mutant mice.
BMC research notes - 20 Feb 2012
Shoji Hirotaka, Toyama Keiko, Takamiya Yoshihiro, Wakana Shigeharu, Gondo Yoichi, Miyakawa Tsuyoshi
Abstract excerpt
BACKGROUND: Disrupted-in-Schizophrenia 1 (DISC1) is considered to be a candidate susceptibility gene for psychiatric disorders, including schizophrenia, bipolar disorder, and major depression. A recent study reported that N-ethyl-N-nitrosourea (ENU)-induced mutations in exon 2 of the mouse Disc1 gene, which resulted in the amino acid exchange of Q31L and L100P, caused an increase in depression-like behavior in 31...
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