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Article

Characterization of striatal phenotypes in heterozygous Disc1 mutant mice, a model of haploinsufficiency.

The Journal of comparative neurology - 1 May 2020

Baskaran Rathinasamy, Lai Chuan-Ching, Li Wai-Yu, Tuan Li-Heng, Wang Chia-Chuan, Lee Lukas J-H, Liu Chih-Min, Hwu Hai-Gwo, Lee Li-Jen

Abstract excerpt

Disrupted-in-Schizophrenia 1 (DISC1) is a susceptibility gene for several psychiatric illnesses. To study the pathogenesis of these disorders, we generated Disc1 mutant mice by introducing the 129S6/SvEv 25-bp deletion Disc1 variants into the C57BL/6J strain. In this study, we used heterozygous Disc1 mutant (Het) mice to evaluate the DISC1 haploinsufficiency model of schizophrenia. No changes in locomotor...

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Identifiers

PMID: 31721208
DOI: 10.1002/cne.24813

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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