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Article

Setd1a Insufficiency in Mice Attenuates Excitatory Synaptic Function and Recapitulates Schizophrenia-Related Behavioral Abnormalities.

Cell reports - 15 Sept 2020

Nagahama Kenichiro, Sakoori Kazuto, Watanabe Takaki, Kishi Yusuke, Kawaji Keita, Koebis Michinori, Nakao Kazuki, Gotoh Yukiko, Aiba Atsu, Uesaka Naofumi, Kano Masanobu

Abstract excerpt

SETD1A encodes a histone methyltransferase whose de novo mutations are identified in schizophrenia (SCZ) patients and confer a large increase in disease risk. Here, we generate Setd1a mutant mice carrying the frameshift mutation that closely mimics a loss-of-function variant of SCZ. Our Setd1a (+/-) mice display various behavioral abnormalities relevant to features of SCZ, impaired excitatory synaptic...

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Identifiers

PMID: 32937141
DOI: 10.1016/j.celrep.2020.108126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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