Article
A dopamine D2 receptor-DISC1 protein complex may contribute to antipsychotic-like effects.
Neuron - 17 Dec 2014
Su Ping, Li Shupeng, Chen Sheng, Lipina Tatiana V, Wang Min, Lai Terence K Y, Lee Frankie H F, Zhang Hailong, Zhai Dongxu, Ferguson Stephen S G, Nobrega José N, Wong Albert H C, Roder John C, Fletcher Paul J, Liu Fang
Abstract excerpt
Current antipsychotic drugs primarily target dopamine D2 receptors (D2Rs), in conjunction with other receptors such as those for serotonin. However, these drugs have serious side effects such as extrapyramidal symptoms (EPS) and diabetes. Identifying a specific D2R signaling pathway that could be targeted for antipsychotic effects, without inducing EPS, would be a significant improvement in the treatment of...
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