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Article

Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice.

Neuropharmacology - 1 Mar 2012

Lipina Tatiana V, Wang Min, Liu Fang, Roder John C

Abstract excerpt

Disrupted-In-Schizophrenia-1 (DISC1) is a strong genetic risk factor associated with psychiatric disorders. Two distinct mutations in the second exon of the DISC1 gene (Q31L and L100P) lead to either depression- or schizophrenia-like behavior in mice. Both phosphodiesterase-4B (PDE4B) and glycogen synthase kinase-3 (GSK-3) have common binding sites on N-terminal region of DISC1 and are implicated into etiology of...

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Share to Cyclic Nucleotide Phosphodiesterases, Type 4
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21376063
DOI: 10.1016/j.neuropharm.2011.02.020

Genes

DISC1
FST

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice.PMID 21376063Read ↗

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DISC1-Dependent Antipsychotic Effects of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) Inhibitor, TC-2153, on MiceSemantic proximity Read ↗

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Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse.Semantic proximity Read ↗

Disrupted‐in‐Schizophrenia‐1 (DISC1)Semantic proximity Read ↗

Comprehensive behavioral analysis of ENU-induced Disc1-Q31L and -L100P mutant mice.Semantic proximity Read ↗

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