Article
Prophylactic valproic acid treatment prevents schizophrenia-related behaviour in Disc1-L100P mutant mice.
PloS one - 1 Jan 2012
Lipina Tatiana V, Haque Fahmida Nipa, McGirr Alexander, Boutros Paul C, Berger Thorsten, Mak Tak W, Roder John C, Wong Albert H C
Abstract excerpt
BACKGROUND: Schizophrenia is a neurodevelopmental disorder with onset early in adulthood. Disrupted-In-Schizophrenia-1 (DISC1) is a susceptibility gene for schizophrenia and other psychiatric disorders. Disc1-L100P mutant mice show behaviors relevant to schizophrenia at 12 weeks, but not at 8 weeks of age, and may be useful for investigating the onset of schizophrenia in early adulthood. METHODS: We investigated...
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