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Article

[Development of animal models for schizophrenia based on clinical evidence: expectation for psychiatrists].

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology - 1 Apr 2009

Noda Yukihiro, Mouri Akihiro, Waki Yukari, Nabeshima Toshitaka

Abstract excerpt

Schizophrenic patients show positive symptoms, negative symptoms and cognitive dysfunction. In humans, phencyclidine (PCP), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, reproduces the schizophrenia-like psychosis including positive symptoms, negative symptoms and cognitive dysfunction. Ketamine, another non-competitive NMDA receptor antagonist, also reproduces a schizophrenia-like psychosis...

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Source

Identifiers

PMID: 19562941

Genes

DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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