Article
Pan-cancer analysis reveals mtDNA copy number as a key determinant of mutational load and disease progression in cancer
2025-11-19
Abstract excerpt
Mitochondrial DNA (mtDNA) copy number determines the functional state of mitochondria and thus, influences cellular energy production, growth, metabolism, and stress response. Variation in mtDNA copy number has been observed across many cancer types and has been linked to changes in gene expression programs. However, whether mtDNA copy number has any influence on mutation accumulation in cancer is unknown. Further...
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Identifiers and source
- Literature Corpus work
- 8eeda12f-064a-518e-9e11-90dcfde1c5b5
- DOI
- 10.1101/2025.11.18.689019