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Mitochondrial DNA alterations in precision oncology: Emerging roles in diagnostics and therapeutics.

Clinics (Sao Paulo, Brazil) - 1 Jan 2025

Murillo Carrasco Alexis Germán, Chammas Roger, Furuya Tatiane Katsue

Abstract excerpt

Mitochondria are dynamic organelles essential for vital cellular functions, including ATP production, apoptosis regulation, and calcium homeostasis. Increasing research has highlighted the significance of mitochondrial DNA (mtDNA) content and alterations in the development and progression of various diseases, including cancer. The high mutation rate and vulnerability of mtDNA to damage make these alterations...

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Identifiers

PMID: 39884256
DOI: 10.1016/j.clinsp.2024.100570
PMCID: PMC11830334

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