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Article

Functional Role of Mitochondrial DNA in Cancer Progression.

International journal of molecular sciences - 31 Jan 2022

Lin Yang-Hsiang, Lim Siew-Na, Chen Cheng-Yi, Chi Hsiang-Cheng, Yeh Chau-Ting, Lin Wey-Ran

Abstract excerpt

Mitochondrial DNA (mtDNA) has been identified as a significant genetic biomarker in disease, cancer and evolution. Mitochondria function as modulators for regulating cellular metabolism. In the clinic, mtDNA variations (mutations/single nucleotide polymorphisms) and dysregulation of mitochondria-encoded genes are associated with survival outcomes among cancer patients. On the other hand, nuclear-encoded genes...

Topics

DNA, Mitochondrial
DNA, Neoplasm
Humans
Mitochondria
Mitochondrial Proteins
Mutation
Neoplasm Proteins
Neoplasms
Polymorphism, Single Nucleotide

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35163579
DOI: 10.3390/ijms23031659
PMCID: PMC8915179

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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