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Article

Prospective of Mitochondrial DNA Variations in Cancer on Genomic Medicine.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 3 Jun 2024

Du Mulong

Abstract excerpt

Mitochondrial DNA (mtDNA) has emerged as a pivotal component in understanding the etiology and susceptibility of cancer. A recent study by Chen and colleagues delineated the germline genetic effect of mtDNA single-nucleotide polymorphisms (SNP) and haplogroups across pan-cancer risk. They identified a subset of mtSNPs and the corresponding risk score, as well as haplogroups A and M7 alongside their genetic...

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PMID: 38826080
DOI: 10.1158/1055-9965.EPI-24-0233

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