Article

Mitochondrial DNA Copy Number Variation Across Human Cancers

2015-06-27

Abstract excerpt

In cancer, mitochondrial dysfunction, through mutations, deletions, and changes in copy number of mitochondrial DNA (mtDNA), contributes to the malignant transformation and progress of tumors. Here, we report the first large-scale survey of mtDNA copy number variation across 21 distinct solid tumor types, examining over 13,000 tissue samples profiled with next-generation sequencing methods. We find a tendency for...

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Literature Corpus work: 74ea5671-bc85-5498-9459-1939677c2430
DOI: 10.1101/021535

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