Article
Generation, function, and prognostic utility of somatic mitochondrial DNA mutations in cancer.
Environmental and molecular mutagenesis - 1 Jun 2010
Kulawiec Mariola, Salk Jesse J, Ericson Nolan G, Wanagat Jonathan, Bielas Jason H
Abstract excerpt
Exciting new studies are increasingly strengthening the link between mitochondrial mutagenesis and tumor progression. Here we provide a comprehensive review and meta-analysis of studies reporting on mitochondrial DNA mutations in common human cancers. We discuss possible mechanisms by which mitochondrial DNA mutations may influence carcinogenesis, outline important caveats for interpreting the detected...
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