Article

Mitochondrial DNA Common Deletion in Cancer: Emerging Evidence and Methodological Challenges

2024-11-28

Abstract excerpt

The 4,977 bp common deletion of the mitochondrial DNA (mtDNA-CD) is a large-scale deletion that has been frequently observed in various cancers in humans. The common deletion mutation affects 7 key genes encoding for several complex subunits essential to the oxidative phosphorylation system. In the last 20 years, the evidence for the presence of mtDNA-CD in cancer has been elusive. This review aims to examine the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1d3f0ba7-c66a-511c-80db-e986fd36dda7
DOI: 10.20944/preprints202411.2152.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial DNA Common Deletion in Cancer: Emerging Evidence and Methodological ChallengesDOI 10.20944/preprints202411.2152.v1Read

Identifying Somatic Mitochondrial DNA Mutations.Semantic proximity Read

Detection methods for mitochondrial DNA heteroplasmy and their potential single-cell applications in cancer.Semantic proximity Read

Comprehensive Molecular Characterization of Mitochondrial Genomes in Human CancersSemantic proximity Read

Mitochondrial DNA alterations in precision oncology: Emerging roles in diagnostics and therapeutics.Semantic proximity Read

Mitochondrial DNA Copy Number Variation Across Human CancersSemantic proximity Read

Accurate and comprehensive analysis of single nucleotide variants and large deletions of the human mitochondrial genome in DNA and single cells.Semantic proximity Read

The mitochondrial DNA common deletion as a potential biomarker of cancer-associated fibroblasts from skin basal and squamous cell carcinomasSemantic proximity Read

Mitochondrial DNA is a major source of driver mutations in cancer.Semantic proximity Read

Comprehensive molecular characterization of mitochondrial genomes in human cancers.Semantic proximity Read

Heteroplasmic mitochondrial DNA mutations in normal and tumour cells.Semantic proximity Read

Pan-cancer analysis reveals mtDNA copy number as a key determinant of mutational load and disease progression in cancerSemantic proximity Read

Generation, function and diagnostic value of mitochondrial DNA copy number alterations in human cancers.Semantic proximity Read