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Mitochondrial DNA copy number alterations: Key players in the complexity of glioblastoma (Review)

24 Jan 2025

Abstract excerpt

Renowned as a highly invasive and lethal tumor derived from neural stem cells in the central nervous system, glioblastoma (GBM) exhibits substantial histopathological variation and genomic complexity, which drive its rapid progression and therapeutic resistance. Alterations in mitochondrial DNA (mtDNA) copy number (CN) serve a crucial role in GBM development and progression, affecting various aspects of tumor...

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PMID: 39886971
DOI: 10.3892/mmr.2025.13443

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