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Article

Generation, function and diagnostic value of mitochondrial DNA copy number alterations in human cancers.

Life sciences - 18 Jul 2011

Yu Man

Abstract excerpt

Mitochondria are key organelles in eukaryotic cells principally responsible for multiple cellular functions. In addition to a plethora of somatic mutations as well as polymorphic sequence variations in mitochondrial DNA (mtDNA), the identification of increased or reduced mtDNA copy number has been increasingly reported in a broad range of primary human cancers, underscoring that accumulation of mtDNA content...

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Identifiers

PMID: 21683715
DOI: 10.1016/j.lfs.2011.05.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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