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Article

Generation, function and diagnostic value of mitochondrial DNA copy number alterations in human cancers.

Life sciences - 18 Jul 2011

Yu Man

Abstract excerpt

Mitochondria are key organelles in eukaryotic cells principally responsible for multiple cellular functions. In addition to a plethora of somatic mutations as well as polymorphic sequence variations in mitochondrial DNA (mtDNA), the identification of increased or reduced mtDNA copy number has been increasingly reported in a broad range of primary human cancers, underscoring that accumulation of mtDNA content...

Topics

DNA, Mitochondrial
DNA, Neoplasm
Gene Dosage
Genetic Markers
Humans
Mutation
Neoplasms
Oxidative Stress
Signal Transduction

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 21683715
DOI: 10.1016/j.lfs.2011.05.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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