Article

Vaccine Induction of Heterologous HIV-1 Neutralizing Antibody B Cell Lineages in Humans

2023-03-14

Abstract excerpt

<h4>Summary</h4> A critical roadblock to HIV vaccine development is the inability to induce B cell lineages of broadly neutralizing antibodies (bnAbs) in humans. In people living with HIV-1, bnAbs take years to develop. The HVTN 133 clinical trial studied a peptide/liposome immunogen targeting B cell lineages of HIV-1 envelope membrane proximal external region (MPER) bnAbs ( NCT03934541 ). Here, we report MPER pep...

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Literature Corpus work: 8ed86841-7cdf-532c-9584-2d43fb956572
DOI: 10.1101/2023.03.09.23286943

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