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Vaccination with mRNA-encoded nanoparticles drives early maturation of HIV bnAb precursors in humans

15 May 2025

Abstract excerpt

A leading HIV vaccine strategy requires a priming immunogen to induce broadly neutralizing antibody (bnAb) precursors, followed by a series of heterologous boosters to elicit somatic hypermutation (SHM) and produce bnAbs. In two randomized, open-label phase 1 human clinical trials, IAVI G002 in the United States and IAVI G003 in Rwanda and South Africa (IAVI, International Aids Vaccine Initiative), we evaluated...

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PMID: 40373112
DOI: 10.1126/science.adr8382

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