Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study.

Nature biotechnology - 7 May 2012

Haynes Barton F, Kelsoe Garnett, Harrison Stephen C, Kepler Thomas B

Abstract excerpt

Failure of immunization with the HIV-1 envelope to induce broadly neutralizing antibodies against conserved epitopes is a major barrier to producing a preventive HIV-1 vaccine. Broadly neutralizing monoclonal antibodies (BnAbs) from those subjects who do produce them after years of chronic HIV-1 infection have one or more unusual characteristics, including polyreactivity for host antigens, extensive somatic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AIDS Vaccines
Share to Antibodies
Share to Biotechnology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Design

Share to HIV Antibodies

Share to Immunogenetics

Share to Neutralization Tests

Share to Vaccines

Source

Open in PubMed Open full text

Identifiers

PMID: 22565972
DOI: 10.1038/nbt.2197
PMCID: PMC3512202

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study.PMID 22565972Read ↗

Vaccine Induction of Heterologous HIV-1 Neutralizing Antibody B Cell Lineages in HumansSemantic proximity Read ↗

Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans.Semantic proximity Read ↗

HIV-1 vaccine immunogen design strategiesSemantic proximity Read ↗

Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies.Semantic proximity Read ↗

Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations.Semantic proximity Read ↗

Initiation of immune tolerance–controlled HIV gp41 neutralizing B cell lineagesSemantic proximity Read ↗

<scp>HIV</scp>‐1 neutralizing antibodies: understanding nature's pathwaysSemantic proximity Read ↗

An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations.Semantic proximity Read ↗

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.Semantic proximity Read ↗

Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutationsSemantic proximity Read ↗

Vaccines and Broadly Neutralizing Antibodies for HIV-1 Prevention.Semantic proximity Read ↗

Antibody-virus co-evolution in HIV infection: paths for HIV vaccine development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.