Determinants of HIV-1 broadly neutralizing antibody induction.

doi:10.1038/nm.4187

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Article

Determinants of HIV-1 broadly neutralizing antibody induction.

Nature medicine - 1 Nov 2016

Rusert Peter, Kouyos Roger D, Kadelka Claus, Ebner Hanna, Schanz Merle, Huber Michael, Braun Dominique L, Hozé Nathanael, Scherrer Alexandra, Magnus Carsten, Weber Jacqueline, Uhr Therese, Cippa Valentina, Thorball Christian W, Kuster Herbert, Cavassini Matthias, Bernasconi Enos, Hoffmann Matthias, Calmy Alexandra, Battegay Manuel, Rauch Andri, Yerly Sabine, Aubert Vincent, Klimkait Thomas, Böni Jürg, Fellay Jacques, Regoes Roland R, Günthard Huldrych F, Trkola Alexandra

Abstract excerpt

Broadly neutralizing antibodies (bnAbs) are a focal component of HIV-1 vaccine design, yet basic aspects of their induction remain poorly understood. Here we report on viral, host and disease factors that steer bnAb evolution using the results of a systematic survey in 4,484 HIV-1-infected individuals that identified 239 bnAb inducers. We show that three parameters that reflect the exposure to antigen-viral load,...

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PMID: 27668936
DOI: 10.1038/nm.4187

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