Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans.

doi:10.1016/j.cell.2024.04.033

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans.

Cell - 6 Jun 2024

Williams Wilton B, Alam S Munir, Ofek Gilad, Erdmann Nathaniel, Montefiori David C, Seaman Michael S, Wagh Kshitij, Korber Bette, Edwards Robert J, Mansouri Katayoun, Eaton Amanda, Cain Derek W, Martin Mitchell, Hwang JongIn, Arus-Altuz Aria, Lu Xiaozhi, Cai Fangping, Jamieson Nolan, Parks Robert, Barr Maggie, Foulger Andrew, Anasti Kara, Patel Parth, Sammour Salam, Parsons Ruth J, Huang Xiao, Lindenberger Jared, Fetics Susan, Janowska Katarzyna, Niyongabo Aurelie, Janus Benjamin M, Astavans Anagh, Fox Christopher B, Mohanty Ipsita, Evangelous Tyler, Chen Yue, Berry Madison, Kirshner Helene, Van Itallie Elizabeth, Saunders Kevin O, Wiehe Kevin, Cohen Kristen W, McElrath M Juliana, Corey Lawrence, Acharya Priyamvada, Walsh Stephen R, Baden Lindsey R, Haynes Barton F

Abstract excerpt

A critical roadblock to HIV vaccine development is the inability to induce B cell lineages of broadly neutralizing antibodies (bnAbs) in humans. In people living with HIV-1, bnAbs take years to develop. The HVTN 133 clinical trial studied a peptide/liposome immunogen targeting B cell lineages of HIV-1 envelope (Env) membrane-proximal external region (MPER) bnAbs (NCT03934541). Here, we report MPER...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to AIDS Vaccines

Share to Antibodies, Neutralizing

Share to B-Lymphocytes

Share to Cell Lineage

Share to env Gene Products, Human Immunodeficiency Virus

Share to HIV Antibodies

Share to HIV Envelope Protein gp41

Share to Liposomes

Source

Open in PubMed

Identifiers

PMID: 38761800
DOI: 10.1016/j.cell.2024.04.033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans.PMID 38761800Read ↗

Vaccine Induction of Heterologous HIV-1 Neutralizing Antibody B Cell Lineages in HumansSemantic proximity Read ↗

An HIV-1 gp41 peptide-liposome vaccine elicits neutralizing epitope-targeted antibody responses in healthy individualsSemantic proximity Read ↗

Germline-Targeting Strategies to Induce bNAbs against HIV-1Semantic proximity Read ↗

Vaccination induces HIV broadly neutralizing antibody precursors in humans.Semantic proximity Read ↗

Determinants of HIV-1 broadly neutralizing antibody induction.Semantic proximity Read ↗

B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study.Semantic proximity Read ↗

Antibody-virus co-evolution in HIV infection: paths for HIV vaccine development.Semantic proximity Read ↗

First clinical study of germline-targeting strategy: One step closer to a successful bnAb-based HIV vaccineSemantic proximity Read ↗

Contemporary HIV-1 envelope pseudovirus panels for detecting and assessing B cell lineages with broadly neutralizing antibody potentialSemantic proximity Read ↗

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.Semantic proximity Read ↗

Vaccination with mRNA-encoded nanoparticles drives early maturation of HIV bnAb precursors in humansSemantic proximity Read ↗

Shared HIV envelope-specific B cell clonotypes induced by a pox-protein vaccine regimenSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.