Germline-Targeting Strategies to Induce bNAbs against HIV-1

Abstract excerpt

Developing an effective HIV-1 vaccine remains a critical global health challenge, hindered by the virus's high genetic diversity, immune evasion strategies, and structural complexity of its Envelope (Env) glycoprotein. Broadly neutralizing antibodies (bNAbs), capable of targeting conserved Env epitopes, offer a promising path for vaccine design. Germline-Targeting (GT) strategies have emerged as a promising...