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An HIV-1 gp41 peptide-liposome vaccine elicits neutralizing epitope-targeted antibody responses in healthy individuals

2024-03-18

Abstract excerpt

Broadly neutralizing antibodies (bnAbs) that target the HIV gp41 membrane-proximal external region (MPER) have some of the highest neutralization breadth. An MPER peptide-liposome vaccine has been found to expand MPER bnAb precursors in monkeys. The HVTN133 phase 1 clinical trial ( NCT03934541 ) studied the MPER peptide-liposome immunogen in 24 HIV-1 seronegative individuals. Participants were randomized in a dos...

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Identifiers and source

Literature Corpus work
c2910955-7dc2-546a-a7c3-67eb7cb34513
DOI
10.1101/2024.03.15.24304305
Open publication

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An HIV-1 gp41 peptide-liposome vaccine elicits neutralizing epitope-targeted antibody responses in healthy individualsDOI 10.1101/2024.03.15.24304305
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