Article
Antibody-virus co-evolution in HIV infection: paths for HIV vaccine development.
Immunological reviews - 1 Jan 2017
Bonsignori Mattia, Liao Hua-Xin, Gao Feng, Williams Wilton B, Alam S Munir, Montefiori David C, Haynes Barton F
Abstract excerpt
Induction of HIV-1 broadly neutralizing antibodies (bnAbs) to date has only been observed in the setting of HIV-1 infection, and then only years after HIV transmission. Thus, the concept has emerged that one path to induction of bnAbs is to define the viral and immunologic events that occur during HIV-1 infection, and then to mimic those events with a vaccine formulation. This concept has led to efforts to map...
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