Article

Transcription-dependent regulation of replication dynamics modulates genome stability

2018-03-22

Abstract excerpt

Replication stress is a primary threat to genome stability and has been implicated in tumorigenesis 1, 2 . Common fragile sites (CFSs) are loci hypersensitive to replication stress 3 and are hotspots for chromosomal rearrangements in cancers 4 . CFSs replicate late in S-phase 3 , are cell-type dependent 4–6 and nest within very large genes 4, 7–9 . The mechanisms responsible for CFS instability are still dis...

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Literature Corpus work: 115c3791-768a-535c-9374-399e6b21ad83
DOI: 10.1101/286807

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