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Article

Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites.

Proceedings of the National Academy of Sciences of the United States of America - 30 Nov 2021

Twayana Shyam, Bacolla Albino, Barreto-Galvez Angelica, De-Paula Ruth B, Drosopoulos William C, Kosiyatrakul Settapong T, Bouhassira Eric E, Tainer John A, Madireddy Advaitha, Schildkraut Carl L

Abstract excerpt

Common fragile sites (CFSs) are difficult-to-replicate genomic regions that form gaps and breaks on metaphase chromosomes under replication stress. They are hotspots for chromosomal instability in cancer. Repetitive sequences located at CFS loci are inefficiently copied by replicative DNA polymerase (Pol) delta. However, translesion synthesis Pol eta has been shown to efficiently polymerize CFS-associated...

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Share to Chromosome Fragile Sites
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34815340
DOI: 10.1073/pnas.2106477118
PMCID: PMC8640788

Genes

POLH

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