Article
Genome-wide high-resolution mapping of mitotic DNA synthesis sites and common fragile sites by direct sequencing.
Cell research - 1 Nov 2020
Ji Fang, Liao Hongwei, Pan Sheng, Ouyang Liujian, Jia Fang, Fu Zaiyang, Zhang Fengjiao, Geng Xinwei, Wang Xinming, Li Tingting, Liu Shuangying, Syeda Madiha Zahra, Chen Haixia, Li Wen, Chen Zhihua, Shen Huahao, Ying Songmin
Abstract excerpt
Common fragile sites (CFSs) are genomic loci prone to the formation of breaks or gaps on metaphase chromosomes. They are hotspots for chromosome rearrangements and structural variations, which have been extensively implicated in carcinogenesis, aging, and other pathological processes. Although many CFSs were identified decades ago, a consensus is still lacking for why they are particularly unstable and sensitive...
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