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Early replication fragile sites are associated with cancer-related CNVs and SNVs in human embryonic stem cells.

Stem cell reports - 14 Jul 2026

Dong Yu-Ping, Qiu Menglin, Tang Haoyu, Shi Wen, Lu Yi, Ji Fang, Liao Hongwei, Ying Songmin, Zheng Ping, Wang Lin

Abstract excerpt

Long-term culture of human embryonic stem cells (hESCs) often induces chromosomal abnormalities, which limits their clinical use. However, the underlying mechanisms are unclear. Early replication fragile sites (ERFSs) are genomic loci susceptible to breakage in early S-phase and serve as hotspots for chromosomal rearrangements, with established links to carcinogenesis. To map ERFSs in hESCs, we established the...

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Identifiers

PMID: 42314676
DOI: 10.1016/j.stemcr.2026.102968
PMCID: PMC13385439

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GC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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