Article

POLQ mediates replication-stress induced structural variant formation throughout common fragile sites during mitosis

2024-05-29

Abstract excerpt

Genomic structural variants (SVs) greatly impact human health and disease, but much is unknown about their generative mechanisms, especially for the large class of nonrecurrent alterations. Common fragile sites (CFSs) are unstable loci that provide a model for SV formation, especially large deletions, under replication stress. We studied SV junction formation as it occurred in cells by applying error-minimized cap...

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Literature Corpus work: 1d09ecca-ff43-5589-9ee0-0766ad08291a
DOI: 10.1101/2024.05.28.596214

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