Article

Evaluating Polygenic Score Transferability for Lipid Traits in Underrepresented Populations: Evidence from Samoan Cohorts

2026-06-30

Abstract excerpt

<h4>ABSTRACT</h4> Dyslipidemia is a significant risk factor for cardiovascular disease (CVD), the leading cause of death in Samoa. 1 Polygenic scores (PGS) for lipid traits offer promise for improved CVD risk prediction, 4,5 yet their performance in Pacific Islander populations — comprising only 0.002% of GWAS participants as of 2024 3 — remains unknown. We evaluated the transferability of multi-ancestry PGS f...

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Literature Corpus work: 8e86cce5-2102-5e57-8386-494bfbf344c8
DOI: 10.64898/2026.06.26.26356725

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