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Article

A new method for multiancestry polygenic prediction improves performance across diverse populations.

Nature genetics - 1 Oct 2023

Zhang Haoyu, Zhan Jianan, Jin Jin, Zhang Jingning, Lu Wenxuan, Zhao Ruzhang, Ahearn Thomas U, Yu Zhi, O'Connell Jared, Jiang Yunxuan, Chen Tony, Okuhara Dayne, Garcia-Closas Montserrat, Lin Xihong, Koelsch Bertram L, Chatterjee Nilanjan

Abstract excerpt

Polygenic risk scores (PRSs) increasingly predict complex traits; however, suboptimal performance in non-European populations raise concerns about clinical applications and health inequities. We developed CT-SLEB, a powerful and scalable method to calculate PRSs, using ancestry-specific genome-wide association study summary statistics from multiancestry training samples, integrating clumping and thresholding,...

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Source

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Identifiers

PMID: 37749244
DOI: 10.1038/s41588-023-01501-z
PMCID: PMC10923245

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