Article

Validity of European-centric derived cardiometabolic polygenic risk scores in multi-ancestry populations

2023-03-20

Abstract excerpt

<h4>ABSTRACT</h4> Polygenic risk scores (PRSs) provide an individual level estimate of genetic risk for any given disease. Since most PRSs have been derived from genome wide association studies (GWAS) conducted in populations of White European ancestry, their validity in other ancestry groups remains unconfirmed. This is especially relevant for cardiometabolic diseases which are known to disproportionately affect...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1a24e660-c51c-52c3-9d3b-7d18d2171dee
DOI: 10.1101/2023.03.20.23287475

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Validity of European-centric derived cardiometabolic polygenic risk scores in multi-ancestry populationsDOI 10.1101/2023.03.20.23287475Read

Validity of European-centric cardiometabolic polygenic scores in multi-ancestry populationsSemantic proximity Read

Polygenic risk scores for cardiometabolic traits demonstrate importance of ancestry for predictive precision medicine.Semantic proximity Read

Polygenic risk scores for cardiometabolic traits demonstrate importance of ancestry for predictive precision medicine.Semantic proximity Read

Bridging traditional risk factors and genetic insights: A review on polygenic risk scores in cardiovascular diseasesSemantic proximity Read

Current State and Future of Polygenic Risk Scores in Cardiometabolic Disease: A Scoping Review.Semantic proximity Read

Ancestry-aligned polygenic scores combined with conventional risk factors improve prediction of cardiometabolic outcomes in African populations.Semantic proximity Read

Associations of cardiometabolic polygenic risk scores with cardiovascular disease in African AmericansSemantic proximity Read

Polygenic risk score portability for common diseases across genetically diverse populationsSemantic proximity Read

Optimization of Multi-Ancestry Polygenic Risk Score Disease Prediction ModelsSemantic proximity Read

Polygenic risk score portability for common diseases across genetically diverse populations.Semantic proximity Read

Transferability of European-derived cardiometabolic polygenic risk scores in the South Asians and their interplay with family historySemantic proximity Read

Polygenic risk scores for the prediction of cardiometabolic disease.Semantic proximity Read