Article

A new method for multi-ancestry polygenic prediction improves performance across diverse populations

2022-03-27

Abstract excerpt

Polygenic risk scores (PRS) increasingly predict complex traits, however, suboptimal performance in non-European populations raise concerns about clinical applications and health inequities. We developed CT-SLEB, a powerful and scalable method to calculate PRS using ancestry-specific GWAS summary statistics from multi-ancestry training samples, integrating clumping and thresholding, empirical Bayes and super learn...

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Literature Corpus work: 4345917e-b0f5-535e-8878-889aec6b8de2
DOI: 10.1101/2022.03.24.485519

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