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Article

Performance of Polygenic Risk Scores for Atherosclerotic Cardiovascular Disease in the All of Us Program.

Circulation. Genomic and precision medicine - 1 Aug 2026

Smith Johanna L, Norland Kristjan, Hamed Marwan E, Yu Yue, Na Jie, Dikilitas Ozan, Schaid Daniel J, Kullo Iftikhar J

Abstract excerpt

BACKGROUND: Performance and transferability of contemporary polygenic risk scores (PRS) for atherosclerotic cardiovascular disease phenotypes may vary across PRS methods, training data, and trait ascertainment. METHODS: We aimed to investigate the performance and transferability of contemporary PRS for atherosclerotic cardiovascular disease subtypes: coronary heart disease (CHD), abdominal aortic aneurysm (AAA),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42253048
DOI: 10.1161/CIRCGEN.125.005382
PMCID: PMC13288946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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