Article

CRISPR Screen in Regulatory T Cells Reveals Ubiquitination Modulators of Foxp3

2020-02-27

Abstract excerpt

Regulatory T cells (Tregs) are required to control immune responses and maintain homeostasis but are a significant barrier to anti-tumor immunity 1 . Conversely, Treg instability, characterized by loss of the master transcription factor Foxp3 and acquisition of pro-inflammatory properties 2 , can promote autoimmunity and/or facilitate more effective tumor immunity 3,4 . A comprehensive understanding of the path...

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Literature Corpus work: 8e74c9b2-31e2-590d-8bff-c151d9a19954
DOI: 10.1101/2020.02.26.966911

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