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Article

FOXP3: genetic and epigenetic implications for autoimmunity.

Journal of autoimmunity - 1 Mar 2013

Katoh Hiroto, Zheng Pan, Liu Yang

Abstract excerpt

FOXP3 plays an essential role in the maintenance of self-tolerance and, thus, in preventing autoimmune diseases. Inactivating mutations of FOXP3 cause immunodysregulation, polyendocrinopathy, and enteropathy, X-linked syndrome. FOXP3-expressing regulatory T cells attenuate autoimmunity as well as immunity against cancer and infection. More recent studies demonstrated that FOXP3 is an epithelial cell-intrinsic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23313429
DOI: 10.1016/j.jaut.2012.12.004
PMCID: PMC3622774

Genes

FOXP3

Provenance

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