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A genome-wide CRISPR screen reveals a role for the BRD9-containing non-canonical BAF complex in regulatory T cells

2020-02-27

Abstract excerpt

<h4>Summary</h4> Regulatory T cells (Tregs) play a pivotal role in suppressing auto-reactive T cells and maintaining immune homeostasis. Treg development and function are dependent on the transcription factor Foxp3. Here we performed a genome-wide CRISPR/Cas9 knockout screen to identify the regulators of Foxp3 in mouse primary Tregs. The results showed that Foxp3 regulators are highly enriched in genes encoding S...

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Literature Corpus work
71efbf2a-d6da-571c-95d3-3f72cc85afc2
DOI
10.1101/2020.02.26.964981
Open publication

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A genome-wide CRISPR screen reveals a role for the BRD9-containing non-canonical BAF complex in regulatory T cellsDOI 10.1101/2020.02.26.964981
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