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Article

Regulatory T cells and Foxp3.

Immunological reviews - 1 May 2011

Rudensky Alexander Y

Abstract excerpt

Regulatory T (Treg) cells play central role in regulation of immune responses to self-antigens, allergens, and commensal microbiota as well as immune responses to infectious agents and tumors. Transcriptional factor Foxp3 serves as a lineage specification factor of Treg cells. Paucity of Treg cells due to loss-of-function mutations of the Foxp3 gene is responsible for highly aggressive, fatal, systemic...

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Identifiers

PMID: 21488902
DOI: 10.1111/j.1600-065X.2011.01018.x
PMCID: PMC3077798

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